ROLE OF HEPATIC-SPECIFIC TRANSCRIPTION FACTORS AND POLYCOMB REPRESSIVE COMPLEX 2 DURING INDUCTION OF FIBROBLASTS TO HEPATIC FATE.

Role of Hepatic-Specific Transcription Factors and Polycomb Repressive Complex 2 during Induction of Fibroblasts to Hepatic Fate.

Direct reprogramming using defined sets of transcription factors (TFs) is a recent strategy for generating induced hepatocytes (iHeps) from fibroblasts for use in regenerative medicine and drug development.Comprehensive studies detailing the regulatory role of TFs during this reprogramming process could help increase its efficiency.This study aimed

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A New Design of Fractal Optical Modulation

In this paper it was designed a new Fuel Filters fractal optical modulation by using a new iteration of fractal function, the result was analyzed by MTF evaluation, and it compared with results of normal optical modulation.The normal and fractal optical modulator is a circular disc which has a radius R=9cm, both of them consist of twenty sectors, t

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Conformational modulation of influenza virus hemagglutinin: characterization and in vivo efficacy of monomeric form

Abstract Mutational changes that mostly occur at the head region of hemagglutinin (HA) lead to the emergence of new epidemic influenza viruses, whereas HA antigens have been modified to generate broadly neutralizing antibodies toward highly conserved epitopes in the HA stem.Interestingly, a recent analysis of serum antibody repertoires showed that

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Free radical exposure creates paler carotenoid-based ornaments: a possible interaction in the expression of black and red traits.

Oxidative stress could be a key selective force shaping the expression of colored traits produced by the primary animal pigments in integuments: carotenoids and melanins.However, the impact of oxidative stress on melanic ornaments has only recently been explored, whereas its role in the expression of carotenoid-based traits is not fully understood.

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